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Recently Identified Immune Cells

Possible Therapeutic Target 
Implications

University of Pennsylvania study for treating the development and severity of atopic dermatitis

The increasing incidence of allergic skin diseases, and the accompanying economic burden and heightened risk of developing other allergic conditions, have spurred researchers to look for better ways to control these immune system-based disorders.

Atopic dermatitis, more commonly called eczema, now affects 10 to 20 percent of children in the United States and direct health-care costs exceed $3 billion, according to the National Institute of Arthritis and

Skin pH: From Basic Science to Basic Skin Care

Abstract:

The "acid mantle" is a topic not only of historical interest, but also of clinical significance and has recently been linked to vital stratum corneum function. Despite compelling basic science evidence placing skin pH as a key factor in barrier homeostasis, stratum corneum integrity, and antimicrobial defense, application of the acid mantle concept in clinical care is lacking. We review recent basic science investigations into skin pH, discuss skin disorders characterized by aberrant pH, and finally discuss practical application for preservation of the acid mantle.

The Persistence of Atopic Dermatitis and Filaggrin (FLG) Mutations in a US Longitudinal Cohort

Since the beginning of this century several studies have been published that have helped to revolutionize our understanding of the pathophysiology of AD. These studies have shown an association between genetic variation and AD.  Genes that have been implicated include genes that code proteins associated with skin barrier and genes that code proteins involved in immune function.

Hand Eczema

Q:  Aside from dry skin all over my body. The main place I get eczema is on my hands. When I have a flare up it seems to start with small (1-2 centimeter), clear-fluid, blister-type bubbles on my hands. The bubbles pop, the skin underneath is exposed, and the eczema starts. It takes about 7 to 10 days to heal—sometimes more, sometimes less. This depends on how much care I give it. That clear fluid blister that formed comes from something inside my body. Can you help me understand this? What is that clear fluid? I think it may be histamine. What causes it to come out on my hands?

Allergic to Chloramine

Dear NEA Scratch Pad:

Several years ago, I was diagnosed with atopic dermatitis. The photo shows the rashes on my back, and there were similar rashes on most of the rest of my body. Fortunately I discovered that the problem was chloramine, a mixture of ammonia and chlorine that is used to disinfect the tap water in many areas of the United States (including the San Francisco Bay area, where I live). After I stopped using our water, my skin cleared up completely. I’m sure there are folks with similar problems who are not aware of this chemical and are suffering as a result.

New Research Fuels Greater Understanding of Atopic Dermatitis and Psoriasis in Children and Adolescents

BOSTON (Aug. 16, 2012)  Information presented at American Academy of Dermatology’s Summer Academy Meeting by Lawrence F. Eichenfield, MD, FAAD, a board-certified pediatric dermatologist, chief, division of pediatric and adolescent dermatology and professor of pediatrics and medicine (dermatology), Rady Children’s Hospital and University of California, San Diego School of Medicine.  Dr. Eichenfield is also a member of the National Eczema Association Scientific Advisory Committee.

OVERVIEW
For the millions of children and adolescents affected by chronic skin conditions such as atopic

Well-moisturized infants less likely to develop eczema

Submitted by Spanish Key
on Sun, 05/27/2012 - 5:52am

Parents who apply moisturizer to their newborns may be able to protect them from developing eczema, a group of American and British researchers report in a new study.

Tags: 
infants
Moisturizing
prevention
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